About   Help   FAQ
Symbol
Name
ID 		Tnf
tumor necrosis factor
MGI:104798
Phenotype annotations related to cardiovascular system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Joint hemorrhage
Bruising susceptibility
Petechiae
Cherry red spot of the macula
Conjunctivitis
Keratoconjunctivitis sicca
Cor pulmonale
Abnormal heart valve morphology
Aortic valve calcification
Mitral valve calcification
Abnormal myocardium morphology
Hypertrophic cardiomyopathy
Abnormal pericardium morphology
Pericarditis
Premature coronary artery atherosclerosis
Vasculitis
Stroke
Elevated diastolic blood pressure
Elevated systolic blood pressure
Hypertension
Raynaud phenomenon
Pulmonary arterial hypertension
Sudden cardiac death
Myocardial infarction
Congestive heart failure
Abnormality of the hepatic vasculature
Lymphadenopathy
Abnormality of the spleen
Splenic infarction
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Erythema
Facial erythema
Disease(s) Associated with TNF
atopic dermatitis
Behcet's disease
beta thalassemia
cerebral infarction
coronary artery disease
cystic fibrosis
Gaucher's disease
Graves' disease
hypochromic microcytic anemia
leprosy
multiple myeloma
pre-eclampsia
rheumatoid arthritis
Sjogren's syndrome
systemic lupus erythematosus
thrombocytopenia

Mouse Phenotypes
abnormal cardiovascular system morphology
abnormal aorta bulb morphology
aortic aneurysm
abnormal lung vasculature morphology
thick mitral valve
increased heart left atrium size
dilated heart atrium
globular heart
increased heart weight
cardiac hypertrophy
abnormal aortic valve morphology
thick aortic valve cusps
aortic valve stenosis
thick aortic valve
abnormal heart ventricle morphology
increased heart ventricle size
dilated heart ventricle
cardiac fibrosis
dilated cardiomyopathy
abnormal cardiovascular system physiology
decreased cardiac output
lung hemorrhage
decreased cardiac muscle contractility
decreased ventricle muscle contractility
abnormal aortic valve flow
cardiac valve regurgitation
cardiovalvulitis
aortic valve inflammation
mitral valve inflammation
decreased heart rate
irregular heartbeat
atrial fibrillation
abnormal impulse conducting system conduction
abnormal atrioventricular node conduction
prolonged HV interval
prolonged QRS complex duration
prolonged QT interval
abnormal myocardial fiber physiology
impaired blood-brain barrier function
myocarditis
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
TnfBpsm1/TnfBpsm1 !
Tnftm2Gkl/Tnftm2Gkl
TnfBpsm1/Tnf+ !
Tnfem4Boui/Tnf+
Tnftm2Gkl/Tnf+
Tg(Myh6-Tnf)1.6Amf/0
Tg(SFTPC-Tnf)2Pva/0
Tg(Tnf)6074Gkl/0
Tg(Myh6-Tnf)1Brgi/?
Tg(Myh6-Tnf)2Brgi/?
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory